技术文章
测量应用案例-20221001
阅读:276 发布时间:2022-10-11
文献名:
Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate
作者
:
Ekaterina S. Naydenko
,
Tatyana Yu. Podlipskaya
,
Yurii M. Yukhin
&
Andrey G. Ogienko
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia ;
摘要:
The objective of this study was to find optimal freeze-drying process parameters to design porous and friable freeze-dried bismuth-potassium-ammonium citrate (FD BPAC) with improved dissolution behavior. The nucleation and melting temperatures of frozen BPAC solution in water and tert-butanol/water co-solvent system were studied with use of thermal analysis. The phases that resulted on cooling were studied by low-temperature powder x-ray diffraction. BPAC formed an amorphous freeze concentrate on cooling and remained amorphous during freeze-drying and subsequent storage. The nucleation of colloidal bismuth subcitrate (CBS) in the FD BPAC and starting BPAC systems in 0.1 M and 0.01 M HCl was studied by dynamic light scattering (DLS) method. The proposed preparation method of FD BPAC can be the basis for design of formulations with enhanced dissolution rate for bismuth-based triple/quadruple therapy, where FD BPAC simultaneously act as a carrier and an active ingredient.
关键词:
Bismuth-potassium-ammonium citrate
,
freeze-drying
,
dynamic light scattering
,
nucleation