文献名： Detection of Chemotherapeutic Drug 6-Mercaptopurine Through Manipulating Localized Surface Plasmon Resonance Absorption of Silver Nanoplates

作者 ：  Qingqing Cai, Li Zhang, Ling Li, Juan Tan, Shiyue Wu, Yi Wang and Wensheng Fu

Engineering Research Center for Biotechnology of Active Substances, Ministry of Education, Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, P. R. China

摘要： A new colorimetric method for the detection of chemotherapeutic drug 6-mercaptopurine (6-MP) is developed based on controlling localized surface plasmon resonance (LSPR) of triangular silver nanoplates (AgNPs). The triangular AgNPs can be etched by trace amount of Cl− and transformed to a disc-like shape, accompanied by a blueshift of the corresponding LSPR absorption band. With the protective effect of 6-MP, the AgNPs are hardly or partly to be etched by Cl−, resulting in a reversed shift of LSPR. Based on a linear relationship between LSPR wavelength change and the concentration of 6-MP, a fast, visual and selective method for 6-MP assay is established. This method has been successfully applied to the detection of 6-MP in tablets.

关键词： Metal nanoparticle; colorimetric assay; pharmaceutical analysis; etching; smartphone