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技术文章

测量应用案例-20220706

阅读:118          发布时间:2022-7-26

文献名: Bi 19 S 27 I 3  nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

作者 Jinsong Xiong,  a    Qinghuan Bian,  a    Shuijin Lei, a    Yatian Deng, a    Kehan Zhao, a    Shunqiang Sun, a    Qi Fu, a    Yanhe Xiao a   and  Baochang Cheng a

a School of Materials Science and Engineering, Nanchang University, Nanchang, Jiangxi 330031, P. R. China

摘要: Near-infrared (NIR) light-induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in photothermal therapy systems, a variety of photothermal agents have been developed. However, the exploration of novel photothermal therapy nanoplatforms with high NIR absorption remains a significant challenge, especially those working in both NIR-I and NIR-II windows. In this work, Bi 19 S 27 I 3  nanorods with remarkably high absorption covering the whole visible light to the entire NIR-I and NIR-II regions have been successfully prepared through a facile solvothermal approach. The as-synthesized Bi 19 S 27 I 3  nanorods have a high photothermal conversion efficiency of 42.7% at 808 nm (NIR-I) and 41.5% at 1064 nm (NIR-II), making them a promising candidate for photothermal therapy. In vitro  cell viability assay reveals that the Bi 19 S 27 I 3  sample has good biocompatibility and exhibits significant cell-killing effect under NIR irradiation. In vivo  anti-tumor experiments demonstrate that the tumor growth can be effectively inhibited by fatal hyperthermia ablation mediated by Bi 19 S 27 I 3  nanorods under the irradiation of an 808 nm or 1064 nm laser. Therefore, this study should be primarily beneficial for the development of new materials for NIR photothermal therapy applications.

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