文献名： Bi ₁₉ S ₂₇ I ₃  nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

作者 ： Jinsong Xiong,  ^a    Qinghuan Bian,  ^a    Shuijin Lei, ^a    Yatian Deng, ^a    Kehan Zhao, ^a    Shunqiang Sun, ^a    Qi Fu, ^a    Yanhe Xiao ^a   and  Baochang Cheng ^a

^a School of Materials Science and Engineering, Nanchang University, Nanchang, Jiangxi 330031, P. R. China

摘要： Near-infrared (NIR) light-induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in photothermal therapy systems, a variety of photothermal agents have been developed. However, the exploration of novel photothermal therapy nanoplatforms with high NIR absorption remains a significant challenge, especially those working in both NIR-I and NIR-II windows. In this work, Bi ₁₉ S ₂₇ I ₃  nanorods with remarkably high absorption covering the whole visible light to the entire NIR-I and NIR-II regions have been successfully prepared through a facile solvothermal approach. The as-synthesized Bi ₁₉ S ₂₇ I ₃  nanorods have a high photothermal conversion efficiency of 42.7% at 808 nm (NIR-I) and 41.5% at 1064 nm (NIR-II), making them a promising candidate for photothermal therapy. In vitro  cell viability assay reveals that the Bi ₁₉ S ₂₇ I ₃  sample has good biocompatibility and exhibits significant cell-killing effect under NIR irradiation. In vivo  anti-tumor experiments demonstrate that the tumor growth can be effectively inhibited by fatal hyperthermia ablation mediated by Bi ₁₉ S ₂₇ I ₃  nanorods under the irradiation of an 808 nm or 1064 nm laser. Therefore, this study should be primarily beneficial for the development of new materials for NIR photothermal therapy applications.

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