技术文章
测量应用案例-20220706
阅读:118 发布时间:2022-7-26
文献名:
Bi
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nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows
作者
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Jinsong Xiong,
a
Qinghuan Bian,
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Shuijin Lei,
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Yatian Deng,
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Kehan Zhao,
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Shunqiang Sun,
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Qi Fu,
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Yanhe Xiao
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and Baochang Cheng
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School of Materials Science and Engineering, Nanchang University, Nanchang, Jiangxi 330031, P. R. China
摘要:
Near-infrared (NIR) light-induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in photothermal therapy systems, a variety of photothermal agents have been developed. However, the exploration of novel photothermal therapy nanoplatforms with high NIR absorption remains a significant challenge, especially those working in both NIR-I and NIR-II windows. In this work, Bi
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nanorods with remarkably high absorption covering the whole visible light to the entire NIR-I and NIR-II regions have been successfully prepared through a facile solvothermal approach. The as-synthesized Bi
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nanorods have a high photothermal conversion efficiency of 42.7% at 808 nm (NIR-I) and 41.5% at 1064 nm (NIR-II), making them a promising candidate for photothermal therapy.
In vitro
cell viability assay reveals that the Bi
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sample has good biocompatibility and exhibits significant cell-killing effect under NIR irradiation.
In vivo
anti-tumor experiments demonstrate that the tumor growth can be effectively inhibited by fatal hyperthermia ablation mediated by Bi
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nanorods under the irradiation of an 808 nm or 1064 nm laser. Therefore, this study should be primarily beneficial for the development of new materials for NIR photothermal therapy applications.
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