您好, 欢迎来到化工仪器网

| 注册| 产品展厅| 收藏该商铺

18611095289

technology

首页   >>   技术文章   >>   重组人的载脂蛋白E2 ApoE2

北京博蕾德科技发展有限公...

立即询价

您提交后,专属客服将第一时间为您服务

重组人的载脂蛋白E2 ApoE2

阅读:1496      发布时间:2013-6-19
分享:

Synonyms :

Apolipoprotein E2

Description :

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.

Catalog #:

350-12

Source :

E.coli

Stability :

The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted ApoE2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.

Purity :

Greater than 90% by SDS-PAGE gel and HPLC analyses.

Endotoxin Level :

Endotoxin level is less than 0.1 ng per µg (1EU/µg).

Biological Activity :

Data not available.

AA Sequence :

MKVEQAVETE PEPELRTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKCL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQA IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH

PubMed Link :

ApoE2

Country of Origin :

USA

 

 

Size A 100µg $75   
 
Size B 500µg $185   
 
Size C 1mg $350 

会员登录

请输入账号

请输入密码

=

请输验证码

收藏该商铺

标签:
保存成功

(空格分隔,最多3个,单个标签最多10个字符)

常用:

提示

您的留言已提交成功!我们将在第一时间回复您~
在线留言